Topiramate (topamax) is an anticonvulsant (treats seizures) that some use in weight loss combinations. Remember the combination fen-phen, which turned out to cause permanent heart valve damage in some people?
Unfortunately, the Mayo Clinic warns:
The anticonvulsant topiramate (Topamax). Normally used to control seizures, topiramate has also been found to reduce binge-eating episodes. However, it can cause serious side effects, including a numb, burning or tingling sensation, and trouble in thinking.
Now, the FDA warns of dangers to fetuses:
Topiramate Use During Pregnancy Increases Risk for Oral Clefts
The FDA recommends that pregnant women and women who may become pregnant should “discuss other treatment options” with their clinicians before starting topiramate.
FDA MedWatch alert (Free)