Jet lag, shift work, and obesity

I’ve just arrived in Hong Kong for a medical conference.  I’m discombobulated.  Jet lagged.

On the plane, I read an article about research in mice showing that keeping them in abnormal chronotropic (night/day) cycle caused them to gain weight, even though they didn’t each much food!  I know I certainly don’t feel very energetic right now.

The authors of the study also cite work in humans showing that nurses who work night shifts are more likely to be obese.  They cite other work that shows that pilots who fly back and forth across time zones actually have some smaller parts of their brains. This seems to be related to higher levels of the stress hormone cortisol.  Is my brain shrinking as I write this?  Does being sleep deprived keep us from making good judgements?

We know that shift work pays more, but it has also been associated with higher rates of cancer, and shorter life spans.  Is it worth it???

More from the scientific article (my highlights):

Circadian (daily) rhythms are present in almost all plants and animals. In mammals, a brain clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between environmental light/dark cycles and physiology and behavior. Over the past 100 y, especially with the advent of electric lighting, modern society has resulted in a round-the-clock lifestyle, in which natural connections between rest/activity cycles and environmental light/dark cycles have been degraded or even broken. Instances in which rapid changes to sleep patterns are necessary, such as transmeridian air travel, demonstrate negative effects of acute circadian disruption on physiology and behavior. However, the ramifications of chronic disruption of the circadian clock for mental and physical health are not yet fully understood. By housing mice in 20-h light/dark cycles, incongruous with their endogenous ∼24-h circadian period, we were able to model the effects of chronic circadian disruption noninvasively. Housing in these conditions results in accelerated weight gain and obesity, as well as changes in metabolic hormones. In the brain, circadian-disrupted mice exhibit a loss of dendritic length and decreased complexity of neurons in the prelimbic prefrontal cortex, a brain region important in executive function and emotional control. Disrupted animals show decreases in cognitive flexibility and changes in emotionality consistent with the changes seen in neural architecture. How our findings translate to humans living and working in chronic circadian disruption is unknown, but we believe that this model can provide a foundation to understand how environmental disruption of circadian rhythms impacts the brain, behavior, and physiology.

Dr John Ellis MD

Board-certified anesthesiologist, with expertise in cardiovascular anesthesia and the implications of obesity and sleep apnea in anesthesia. See for professional information. Dr. Ellis has used the strategies in here to: (1) lose 120 lbs over 18 months, (2) stop all antihypertensive medicines, and (3) no longer need CPAP treatment for sleep apnea.

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